{"id":770,"date":"2016-11-24T16:15:43","date_gmt":"2016-11-24T07:15:43","guid":{"rendered":"http:\/\/minna-hiroba.com\/iryou\/?p=770"},"modified":"2016-11-24T16:15:43","modified_gmt":"2016-11-24T07:15:43","slug":"%e6%b4%bb%e6%80%a7%e9%85%b8%e7%b4%a0%e3%81%8c%e7%82%8e%e7%97%87%e3%83%bb%e3%82%a2%e3%83%ac%e3%83%ab%e3%82%ae%e3%83%bc%e5%8f%8d%e5%bf%9c%e3%82%92%e6%b4%bb%e6%80%a7%e5%8c%96%e3%81%99%e3%82%8b%e6%96%b0","status":"publish","type":"post","link":"http:\/\/naosuzo-mystyle.com\/tounyoubyou\/?p=770","title":{"rendered":"\u6d3b\u6027\u9178\u7d20\u304c\u708e\u75c7\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b0\u305f\u306a\u4ed5\u7d44\u307f\u306e\u767a\u898b"},"content":{"rendered":"

 <\/p>\n

\u6d3b\u6027\u9178\u7d20\u304c\u708e\u75c7\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b0\u305f\u306a\u4ed5\u7d44\u307f\u306e\u767a\u898b<\/h1>\n

\uff0d\u611f\u67d3\u9632\u5fa1\uff08\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\uff09\u306b\u304a\u3051\u308b\u65b0\u305f\u306a\u7d30\u80de\u5185\u5206\u5b50\u6a5f\u69cb\uff0d<\/h2>\n

 <\/p>\n

\n
\u3000\uff2a\uff33\uff34\uff08\u7406\u4e8b\u9577\uff1a\u6c96\u6751\u61b2\u6a39\uff09\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u6d3b\u6027\u9178\u7d20\u304c\u75c5\u539f\u4f53\u611f\u67d3\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u708e\u75c7\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u3001\u305d\u306e\u6d3b\u6027\u9178\u7d20\u306e\u4f5c\u7528\u3092\u53d7\u3051\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u304cASK1\uff08Apoptosis signal-regulating kinase 1\uff09\uff0a\uff11<\/span><\/sup><\/span><\/u><\/span><\/a>\u3068\u3044\u3046\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3067\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u305f\u3002<\/div>\n
<\/div>\n
\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306b\u611f\u67d3\u3059\u308b\u3068\u3001\u305d\u308c\u3089\u3092\u4f53\u5185\u304b\u3089\u8fc5\u901f\u306b\u6392\u9664\u3059\u308b\u305f\u3081\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\uff0a\uff12<\/span><\/sup><\/span><\/u><\/span><\/a>\u3068\u3044\u3046\u751f\u4f53\u5185\u9632\u5fa1\u6a5f\u69cb\u304c\u6d3b\u6027\u5316\u3059\u308b\u3002\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u3072\u3068\u305f\u3073\u75c5\u539f\u4f53\u306e\u611f\u67d3\u3092\u611f\u77e5\u3059\u308b\u3068\u514d\u75ab\u5fdc\u7b54\u306b\u5fc5\u9808\u306a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff0a\uff13<\/span><\/sup><\/span><\/u><\/span><\/a>\u304c\u7523\u751f\u3055\u308c\u3001\u751f\u4f53\u5185\u3067\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/div>\n
<\/div>\n
\u4e00\u65b9\u3067\u3001\u306a\u3093\u3089\u304b\u306e\u539f\u56e0\u306b\u3088\u308a\u3053\u308c\u3089\u306e\u9632\u5fa1\u53cd\u5fdc\u304c\u7570\u5e38\u306b\u4ea2\u9032\u3059\u308b\u3068\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u539f\u56e0\u306b\u3082\u306a\u308b\u3002\u75c5\u539f\u4f53\u306e\u611f\u77e5\u306b\u306f\u3001\u7d30\u80de\u819c\u53d7\u5bb9\u4f53\u3067\u3042\u308bTLR\u30d5\u30a1\u30df\u30ea\u30fc\uff0a\uff14<\/span><\/sup><\/span><\/u><\/span><\/a>\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u3046\u3061\u3001TLR4\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306b\u4f34\u3063\u3066\u7279\u7570\u7684\u306b\u6d3b\u6027\u9178\u7d20\u304c\u7523\u751f\u3055\u308c\u3001<\/div>\n
<\/div>\n
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<\/div>\n
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\n\u672c\u6210\u679c\u306f\u3001\u6226\u7565\u7684\u5275\u9020\u7814\u7a76\u63a8\u9032\u4e8b\u696d\u30c1\u30fc\u30e0\u578b\u7814\u7a76\uff08CREST\u30bf\u30a4\u30d7\uff09\u306e\u7814\u7a76\u30c6\u30fc\u30de\u300c\u30b9\u30c8\u30ec\u30b9\u306e\u53d7\u5bb9\u30fb\u8a8d\u8b58\u3068\u30b7\u30b0\u30ca\u30eb\u5909\u63db\u306e\u5206\u5b50\u6a5f\u69cb\u300d\u306e\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e00\u689d\u79c0\u61b2\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7cfb\u7814\u7a76\u79d1 \u6559\u6388\uff09\u3001\u304a\u3088\u3073\u677e\u6ca2\u539a\uff08\u540c \u52a9\u624b\uff09\u3089\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u3082\u306e\u3067\u30012005\u5e74\uff15\u6708\uff11\u65e5\u4ed8\u306e\u7c73\u56fd\u79d1\u5b66\u96d1\u8a8c\u300cNature Immunology\u300d\u30aa\u30f3\u30e9\u30a4\u30f3\u901f\u5831\u7248\u3067\u516c\u958b\u3055\u308c\u308b\u3002<\/div>\n<\/div>\n

 
\n<\/p>\n

<\/h1>\n
\n

\u3010\u6210\u679c\u306e\u6982\u8981\u3011<\/h3>\n

\u7814\u7a76\u306e\u80cc\u666f\u3068\u7d4c\u7def:<\/strong> \u3000\u5168\u3066\u306e\u751f\u7269\u306f\u3001\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u5fae\u751f\u7269\u306e\u4f53\u5185\u3078\u306e\u611f\u67d3\u30fb\u4fb5\u5165\u306b\u5bfe\u3057\u3066\u3001\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3068\u3044\u3046\u751f\u4f53\u5185\u9632\u5fa1\u6a5f\u69cb\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u305d\u308c\u3089\u3092\u4f53\u5185\u304b\u3089\u3059\u3070\u3084\u304f\u6392\u9664\u3059\u308b\u4ed5\u7d44\u307f\u3092\u5099\u3048\u3066\u3044\u308b\u3002\u751f\u7269\u304c\u6b7b\u306c\u3068\u3059\u3050\u306b\u8150\u6557\u3057\u3066\u3057\u307e\u3046\u306e\u306f\u3001\u5fae\u751f\u7269\u306e\u4fb5\u5165\u306b\u8ca0\u3051\u3066\u3057\u307e\u3046\u304b\u3089\u3067\u3042\u308a\u3001\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306f\u751f\u547d\u306b\u3068\u3063\u3066\u6b20\u304b\u305b\u306a\u3044\u3002\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u3072\u3068\u305f\u3073\u75c5\u539f\u4f53\u306e\u611f\u67d3\u3092\u611f\u77e5\u3059\u308b\u3068\u3001\u307e\u305a\u514d\u75ab\u5fdc\u7b54\u306b\u5fc5\u9808\u306a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u7523\u751f\u3055\u308c\u3001\u751f\u4f53\u5185\u3067\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u3055\u307e\u3056\u307e\u306a\u514d\u75ab\u7cfb\u306b\u95a2\u308f\u308b\u7d30\u80de\u3084\u7d30\u83cc\u3092\u6bba\u3059\u305f\u3081\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3001\u611f\u67d3\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u5834\u6240\u306b\u52d5\u54e1\u3057\u3066\u75c5\u539f\u4f53\u3092\u6392\u9664\u3059\u308b\u3002
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\n\u4eca\u56de\u306e\u8ad6\u6587\u306e\u6982\u8981:<\/strong> \u3000\u4e00\u689d\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u75c5\u539f\u4f53\u3092\u611f\u77e5\u3059\u308b\u7d30\u80de\u819c\u53d7\u5bb9\u4f53\u3067\u3042\u308bTLR\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u3046\u3061\u3001TLR4\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306b\u4f34\u3063\u3066\u7279\u7570\u7684\u306b\u6d3b\u6027\u9178\u7d20\u304c\u7523\u751f\u3055\u308c\u3001\u3055\u3089\u306b\u6d3b\u6027\u9178\u7d20\u3092\u4ecb\u3057\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3067\u3042\u308bASK1\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u52b9\u7387\u3088\u304f\u7523\u751f\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002
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\n <\/p>\n\n\n\n\n\n
\u7528\u8a9e\u8aac\u660e<\/span><\/u><\/a><\/td>\n<\/tr>\n
\u56f31\uff1a\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308b\u75c5\u539f\u4f53\u611f\u67d3\u306e\u611f\u77e5\u3068\u5fdc\u7b54<\/span><\/u><\/a><\/td>\n<\/tr>\n
\u56f32\uff1a\u6d3b\u6027\u9178\u7d20\u3092\u4ecb\u3057\u305fASK1\u306b\u3088\u308b\u65b0\u305f\u306a\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u6d3b\u6027\u5316\u6a5f\u69cb<\/span><\/u><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 \n<\/p><\/div>\n


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