{"id":2455,"date":"2017-03-04T19:57:28","date_gmt":"2017-03-04T10:57:28","guid":{"rendered":"http:\/\/naosuzo.net\/?p=2455"},"modified":"2017-03-04T19:57:28","modified_gmt":"2017-03-04T10:57:28","slug":"%e5%96%ab%e7%85%99%e3%81%ab%e3%82%88%e3%81%a3%e3%81%a6%e6%85%a2%e6%80%a7%e9%96%89%e5%a1%9e%e6%80%a7%e8%82%ba%e6%b0%97%e8%85%ab%e3%81%ae%e7%99%ba%e7%97%87%e3%81%8c%e6%97%a9%e3%81%be%e3%82%8b%e3%83%a1","status":"publish","type":"post","link":"http:\/\/naosuzo-mystyle.com\/seikatsu\/2017\/03\/04\/%e5%96%ab%e7%85%99%e3%81%ab%e3%82%88%e3%81%a3%e3%81%a6%e6%85%a2%e6%80%a7%e9%96%89%e5%a1%9e%e6%80%a7%e8%82%ba%e6%b0%97%e8%85%ab%e3%81%ae%e7%99%ba%e7%97%87%e3%81%8c%e6%97%a9%e3%81%be%e3%82%8b%e3%83%a1\/","title":{"rendered":"\u55ab\u7159\u306b\u3088\u3063\u3066\u6162\u6027\u9589\u585e\u6027\u80ba\u6c17\u816b\u306e\u767a\u75c7\u304c\u65e9\u307e\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e"},"content":{"rendered":"<p class=\"publisher\">\u72ec\u7acb\u884c\u653f\u6cd5\u4eba 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class=\"section\">\n<h3>\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u55ab\u7159\u304c\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u3092\u4f5c\u308a\u51fa\u3059\u9175\u7d20\u300cFut8\u300d\u306e\u5408\u6210\u30fb\u6d3b\u6027\u3092\u4f4e\u4e0b<\/li>\n<li>\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u306e\u6e1b\u5c11\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u9175\u7d20\u306e\u904e\u5270\u6d3b\u6027\u5316\u306b\u3088\u308b\u80ba\u80de\u7834\u58ca\u3092\u5f15\u304d\u8d77\u3053\u3059<\/li>\n<li>COPD\u306e\u4e88\u9632\u3001\u65e9\u671f\u8a3a\u65ad\u3001\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306e\u77e5\u898b\u3068\u3057\u3066\u671f\u5f85<\/li>\n<\/ul>\n<\/div>\n<div id=\"summary\" class=\"section\">\n<h3>\u8981\u65e8<\/h3>\n<p>\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u91ce\u4f9d\u826f\u6cbb\u7406\u4e8b\u9577\uff09\u306f\u3001\u55ab\u7159\u306b\u3088\u308a<a href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#note1\"><u><span style=\"color: #0066cc;\">\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396<sup><span style=\"font-size: small;\">\u203b1<\/span><\/sup><\/span><\/u><\/a>\u306e\u4fee\u98fe\u304c\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u3067\u80ba\u80de\u58c1\u304c\u7834\u58ca\u3055\u308c\u3001\u6162\u6027\u9589\u585e\u6027\u80ba\u6c17\u816b\uff08COPD\uff09\u306e\u767a\u75c7\u304c\u65e9\u307e\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u7406\u7814\u57fa\u5e79\u7814\u7a76\u6240\uff08\u7389\u5c3e\u7693\u5e73\u6240\u9577\uff09\u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u9818\u57df\u75be\u60a3\u7cd6\u9396\u7814\u7a76\u30c1\u30fc\u30e0\/\u962a\u5927\u7523\u7814\uff0d\u7406\u7814\u30a2\u30e9\u30a4\u30a2\u30f3\u30b9\u30e9\u30dc\u306e\u8c37\u53e3\u76f4\u4e4b\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u3001\u9ad8\u53e2\u7b11\u7814\u7a76\u54e1\u3068\u3001\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u547c\u5438\u5668\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u5185\u79d1\u306e\u524d\u91ce\u654f\u5b5d\u8b1b\u5e2b\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308b\u6210\u679c\u3067\u3059\u3002<br \/>\nCOPD\u306f\u3001\u9178\u7d20\u3068\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u4ea4\u63db\u3059\u308b\u80ba\u80de\u304c\u7834\u58ca\u3055\u308c\u308b\u80ba\u6c17\u816b\u3068\u6162\u6027\u6c17\u7ba1\u652f\u708e\u306e\u7dcf\u79f0\u3067\u3001\u6c17\u9053\u9589\u585e\u306b\u3088\u308b\u547c\u5438\u56f0\u96e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306b\u611f\u67d3\u3059\u308b\u3068\u6025\u6fc0\u306b\u75c7\u72b6\u304c\u60aa\u5316\u3057\u3001\u6b7b\u4ea1\u7387\u304c\u975e\u5e38\u306b\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u308f\u304c\u56fd\u3092\u542b\u3081\u4e16\u754c\u7684\u306b\u60a3\u8005\u6570\u304c\u591a\u304f\u3001\u305d\u306e\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u55ab\u7dca\u306e\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002COPD\u767a\u75c7\u306b\u306f\u55ab\u7159\u306a\u3069\u306e\u5916\u7684\u8981\u56e0\u3068\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3067\u3001\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u306e\u6e1b\u5c11\u304cCOPD\u767a\u75c7\u306e\u8981\u56e0\u306e1\u3064\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u55ab\u7159\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002<br \/>\n\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u55ab\u7159\u3068\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u306e\u6e1b\u5c11\u306e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001<a href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#note2\"><u><span style=\"color: #0066cc;\">Fut8\u30d8\u30c6\u30ed\u6b20\u640d\u30de\u30a6\u30b9<sup><span style=\"font-size: small;\">\u203b2<\/span><\/sup><\/span><\/u><\/a>\u306b\u55ab\u7159\u3055\u305b\u3001\u7d4c\u904e\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6b63\u5e38\u306a\u30de\u30a6\u30b9\u306b\u6bd4\u3079\u30662\u500d\u65e9\u304fCOPD\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u55ab\u7159\u306b\u3088\u308a\u3053\u306e\u30de\u30a6\u30b9\u306e\u80ba\u7d44\u7e54\u3067\u306f\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u304c\u6e1b\u5c11\u3057\u3001\u305d\u308c\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u306e<a href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#note3\"><u><span style=\"color: #0066cc;\">MMP<sup><span style=\"font-size: small;\">\u203b3<\/span><\/sup><\/span><\/u><\/a>\u3092\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3057\u3066\u3001\u80ba\u80de\u58c1\u3092\u7834\u58ca\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u3053\u308c\u3089\u306e\u3053\u3068\u306f\u3001\u55ab\u7159\u306b\u3088\u3063\u3066\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u7cd6\u9396\u306e\u5408\u6210\u963b\u5bb3\u304c\u9032\u307f\u3001COPD\u767a\u75c7\u3092\u65e9\u3081\u3066\u75c7\u72b6\u3092\u60aa\u5316\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001Fut8\u30d8\u30c6\u30ed\u6b20\u640d\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u55ab\u7159\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308bCOPD\u306e\u75c5\u614b\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u30d2\u30c8\u306b\u5bfe\u3059\u308bCOPD\u306e\u4e88\u9632\u3001\u65e9\u671f\u8a3a\u65ad\u3001\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3082\u306e\u3068\u3057\u3066\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u306e\u79d1\u5b66\u96d1\u8a8c\u300e<i>The Journal of Biological Chemistry<\/i>\u300f\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff083\u670820\u65e5\u4ed8\u3051\uff1a\u65e5\u672c\u6642\u95933\u670821\u65e5\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\n<\/div>\n<div id=\"PressBodyText\" class=\"section\">\n<h3>\u80cc\u666f<\/h3>\n<p>\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\uff08COPD\uff09\u306f\u3001\u80ba\u6c17\u816b\u3068\u6162\u6027\u6c17\u7ba1\u652f\u708e\u306e\u7dcf\u79f0\u3067\u3001\u6c17\u9053\u9589\u585e\u306b\u3088\u308b\u547c\u5438\u56f0\u96e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u901a\u5e38\u3001\u9178\u7d20\u3068\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u4ea4\u63db\u3059\u308b\u80ba\u306e\u80ba\u80de\u69cb\u9020\u306f\u3001\u80ba\u80de\u58c1\u6210\u5206\u306e\u5408\u6210\u3068\u305d\u306e\u5206\u89e3\u3092\u62c5\u3046\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMP\uff09\u306e\u5236\u5fa1\u306b\u3088\u3063\u3066\u7dad\u6301\u3055\u308c\u307e\u3059\u304c\u3001\u55ab\u7159\u306a\u3069\u306b\u3088\u308aMMP\u304c\u7570\u5e38\u6d3b\u6027\u5316\u3059\u308b\u3068\u80ba\u80de\u58c1\u304c\u7834\u58ca\u3055\u308c\u3001COPD\u304c\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\u30d8\u30d3\u30fc\u30b9\u30e2\u30fc\u30ab\u30fc\u306e2\u5272\u304c\u767a\u75c7\u3057\u3001530\u4e07\u4eba\u3092\u8d8a\u3048\u308b\u6f5c\u5728\u7684\u60a3\u8005\u304c\u3044\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\uff08\u51fa\u5178\uff1a\u9806\u5929\u5802\u5927\u5b66\u533b\u5b66\u90e8\u798f\u5730\u7fa9\u4e4b\u52a9\u5ba2\u54e1\u6559\u6388\u3089\u306b\u3088\u308bNippon COPD Epidemiology (NICE)study\u30012001\u5e74\uff09\u3002\u307e\u305f\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306e\u611f\u67d3\u306b\u3088\u308a\u75c7\u72b6\u304c\u60aa\u5316\u3059\u308b\u3068\u6b7b\u4ea1\u7387\u308215\uff05\u306b\u9054\u3057\u307e\u3059\uff08\u51fa\u5178\uff1aEur. Respir. J. 37: 508-515,2011\uff09\u30021997\u5e74\u306e\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306e\u5831\u544a\u3067\u306f\u3001COPD\u306f\u5168\u4e16\u754c\u306e\u6b7b\u4ea1\u539f\u56e0\u306e4\u4f4d\u3067\u3042\u308a\u30012020\u5e74\u306b\u306f3\u4f4d\u306b\u306a\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3001\u4e88\u9632\u3001\u767a\u75c7\u3001\u75c7\u72b6\u60aa\u5316\u306e\u6291\u5236\u3001\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u793e\u4f1a\u7684\u55ab\u7dca\u306e\u8ab2\u984c\u3067\u3059\u3002COPD\u306e\u767a\u75c7\u306f\u3001\u55ab\u7159\u306a\u3069\u306e\u5916\u7684\u8981\u56e0\u3068\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n1996\u5e74\u306b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4e16\u754c\u306b\u3055\u304d\u304c\u3051\u3066\u8ee2\u79fb\u9175\u7d20Fut8\u306e\u7cbe\u88fd\u3001\u907a\u4f1d\u5b50\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002Fut8\u306fN\u578b\u7cd6\u9396\u306e\u57fa\u90e8\u306b\u30d5\u30b3\u30fc\u30b9\u3092\u4ed8\u3051\u3001\u30b3\u30a2\u30d5\u30b3\u30fc\u30b9\u69cb\u9020\u3092\u4f5c\u308b\u9175\u7d20\u3067\u3059<a href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#fig1\"><u><span style=\"color: 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href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#note4\"><u><span style=\"color: #0066cc;\">\u55ab\u7159\u88c5\u7f6e<sup><span style=\"font-size: small;\">\u203b4<\/span><\/sup><\/span><\/u><\/a>\u3092\u4f7f\u3063\u3066\u5b9f\u9a13\u7528\u30bf\u30d0\u30b3\u30921\u65e54\u672c\u90316\u65e5\u30013\u30ab\u6708\u9593\u55ab\u7159\u3055\u305b\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u55ab\u7159\u6b63\u5e38\u30de\u30a6\u30b9\u3068\u6bd4\u3079\u3066\u55ab\u7159Fut8\u30d8\u30c6\u30ed\u6b20\u640d\u30de\u30a6\u30b9\u306e\u80ba\u3067\u306fFut8\u306e\u5408\u6210\u3084\u9175\u7d20\u6d3b\u6027\u304c\u7d0450\uff05\u306b\u4f4e\u4e0b\u3057\u3066\u304a\u308a\u3001\u55ab\u7159\u5f8c2\u9031\u9593\u306e\u80ba\u30672\u500d\u4ee5\u4e0a\u306eMMP\u306e\u6d3b\u6027\u5316\u304c\u8d77\u3053\u308a\u30013\u30ab\u6708\u5f8c\u306b\u306f\u80ba\u80de\u306e\u69cb\u9020\u304c\u7834\u58ca\u3055\u308c\u308b\u3053\u3068\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f<a href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#fig2\"><u><span style=\"color: #0066cc;\">\uff08\u56f32\uff09<\/span><\/u><\/a>\u3002\u3053\u308c\u306b\u3088\u308a\u3001Fut8\u30d8\u30c6\u30ed\u6b20\u640d\u30de\u30a6\u30b9\u306b\u55ab\u7159\u3055\u305b\u308b\u3068\u55ab\u7159\u6b63\u5e38\u30de\u30a6\u30b9\u3088\u308a2\u500d\u65e9\u304f\u80ba\u6c17\u816b\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u55ab\u7159\u6642\u306eFut8\u30d8\u30c6\u30ed\u6b20\u640d\u30de\u30a6\u30b9\u80ba\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3084\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u6b63\u5e38\u30de\u30a6\u30b9\u306e\u80ba\u7d30\u80de\u3067\u306f\u3001<a href=\"http:\/\/www.riken.jp\/pr\/press\/2012\/20120404\/#note5\"><u><span style=\"color: #0066cc;\">TGF\uff0d\u03b2<sup><span style=\"font-size: 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